• Natural and synthetic glucocorticoids perform their biologic

  2019-11-16

  

  Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.

• Collagen X is a homotrimeric molecule of three X chains

  2019-11-16

  

  Collagen X is a homotrimeric molecule of three α1(X) chains (Mr 59 kDa) comprising a 45 kDa triple-helical domain flanked by an N-terminal (NC2) and a larger C-terminal (NC1) non-collagenous domains (Shen, 2005). In the hypertrophic ECM, collagen X most likely forms an extended hexagonal network, as

• The importance of G S phase progression to

  2019-11-16

  

  The importance of G1–S phase progression to the formation of malignant tumors has been highlighted by the high incidence of aberrations in the genes involved in this progression in a wide variety of tumors. p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors (CKI). Its ro

• The interest for lanthanide and actinide

  2019-11-16

  

  The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM). Lanthanide SMMs are interesting due to large their intrinsic magnetic anisotropy, but their core 4f orbitals minimally participate in exchange inte

• br Disclosures br Introduction The presence

  2019-11-16

  

  Disclosures Introduction The presence of anti-viral T-cell immunity is crucial for effective and sustained protection against Cytomegalovirus (CMV) following allogeneic stem cell transplantation (alloSCT) [1]. In vitro and in vivo T-cell depletion (TCD) via addition of the anti-CD52 monoclonal

• Data on optimal hormone formulations routes of administratio

  2019-11-16

  

  Data on optimal hormone formulations, routes of administration, doses and duration of hormone use in young women with POF are lacking (Box 1). Transdermal SW033291 sale administration, which avoids the first-pass hepatic circulation and the increase in inflammatory markers such as C-reactive protei

• br Experimental br Results and discussion On the basis

  2019-11-16

  

  Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it p-Cresyl sulfate is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the con

• In conclusion our study has

  2019-11-16

  

  In conclusion, our study has demonstrated that PGE2 stimulates expression of survivin in hepatocellular carcinoma cells. Although there are 4 subtypes of EP receptors, the EP1 receptor appears to be the predominant receptor that regulates PGE2-induced expression of survivin, mainly through trans-act

• In vitro studies in NSCLC cell lines

  2019-11-15

  

  In vitro studies in NSCLC cell lines expressing EGFR mutants (T790M mutation, exon 19 deletion E746-A750, L858R/T790M double mutation), demonstrated that Rociletinib potently inhibits proliferation in the mutant EGFR NSCLC 1080 6 with Growth inhibition (GI50) values ranging from 7 to 32 nmol/L. In

• Cell migration and invasion are central processes in the

  2019-11-15

  

  Cell migration and invasion are central processes in the development and metastasis of cancer. The regulation of cell migration by DDR1 has been reported in many types of cancer cell lines; however, conflicting results have been reported regarding the inhibitory as well as promotive effects of DDR1

• Tumor associated macrophages TAMs one of

  2019-11-15

  

  Tumor-associated macrophages (TAMs)—one of the limiting factors in anti-tumor immunity—are associated with the poor clinical outcome in most carcinomas, owing to their potential to promote angiogenesis and local invasion, increase the metastasis of tumor cells, and inhibit the anti-tumor immunity.11

• Acidic substituents showed moderate biochemical activity

  2019-11-15

  

  Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic crth2 antagonist were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of their bioche

• Tumor cells exposed to the effect of these compounds

  2019-11-15

  

  Tumor rhein exposed to the effect of these compounds were shown to become chemo and radio-sensitive. Based on that, it was possible to anticipate the selectivity requirement for DNA-PK inhibition and the best route for their development. Accordingly, prompted by the clinical significance and the th

• Transcription can also be impaired

  2019-11-15

  

  Transcription can also be impaired by lesions in the template DNA strand, which may lead to stalling of RNA polymerase (RNAP) or to transcriptional mutagenesis, thus producing mutant RNAs and proteins [[3], [4], [5], [6], [7]]. At the same time, RNAP can act as a sensor for DNA lesions, by attractin

• br Anti inflammatory effects of MTX In addition to

  2019-11-15

  

  Anti-inflammatory effects of MTX In addition to cytotoxic and cytostatic effects, the anti-inflammatory activity of MTX was also described by several studies. Inhibition of ATIC by MTX has been found to result in the accumulation of 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranosyl 5′-monophosp

16310 records 951/1088 page Previous Next First page 上5页 951952953954955 下5页 Last page