• br Acknowledgements This work was supported by

  2020-07-27

  

  Acknowledgements This work was supported by the National Natural Science Foundation of China (40976065, 41576116). Introduction Arachidonic Irinotecan via cytochrome P-450 (CYP450) can elicit the formation of lipid mediators with vasoactive actions: the epoxyeicosatrienoic acids (EETs) mainl

• Microsomal fractions of earthworm tissue

  2020-07-27

  

  Microsomal fractions of earthworm tissue were prepared as per a previous study with modifications (Zhang et al., 2006). Briefly, the earthworm tissue samples transferred into cold 0.15 mol l−1 KCl solution and were cut into shreds. The remaining solid tissue homogenized for 30 min at 8000 r.min−1. T

• In our recent work we established a

  2020-07-27

  

  In our recent work, we established a different and new strategy to overcome the immunogenicity problem. We showed that isolation of a novel form of the protein used with different epitops could also minimize the patient immune response. We showed that the antibody of one form of the enzyme does not

• Consistent with prior reports this

  2020-07-25

  

  Consistent with prior reports, this study also found the level of 11 cytokines (MIF, IL-1Ra, CTACK, M-CSF, Basic FGF, VCAM-1, SDF-1α, IL-8, IL-16, PDGF-β, and GRO-α) significantly decreased in the sera of adult HFMD patients in comparison with controls. MIF is a pro-inflammaory cytokine that is asso

• Orange spotted grouper Epinephelus coioides

  2020-07-25

  

  Orange-spotted grouper (Epinephelus coioides) is a coral reef fish with a high commercial value in China and Southeast Asian countries. However, in recent years, various outbreaks of viral diseases have affected the grouper aquaculture industry (Wei et al., 2010). Specifically, Singapore grouper iri

• The assessment process is even

  2020-07-25

  

  The assessment process is even more difficult when Commercial-Off-The-Shelf (COTS) components – whose internals are partially or totally unknown – come into play. COTS are being increasingly used by the industry to reduce costs and to shorten development (and possibly deployment) time. However, sinc

• The present study has shown that

  2020-07-25

  

  The present study has shown that additional protein stability can be achieved (Fig. 6). The 0.6 to 1.0 °C increases that were observed were not large compared, for example, to the ∼5 °C increase that has been reported using sequence modifications [22]. This may reflect that the Hyp enters both the X

• Apelin-13 The P H activity and the large number

  2020-07-25

  

  The P4H activity and the large number of 4-Hyp residues that are formed, amounting to half of all the Pro residues or 10% of all residues, have been identified as having a clear role in the structure and chemistry of the triple helix [3]. The role of the rare 3-Hyp residues is less clear and is stil

• The substitution of serine by an alanine

  2020-07-25

  

  The substitution of serine 185 by an alanine led to an increase of EGF-R stabilization along with a better binding of PRK1, a RhoB effector described to be involved in EGF-R intracellular traffic. Overall these data indicated that the phosphate group on serine 185 impaired its binding to the effecto

• Apparently no study has been undertaken

  2020-07-25

  

  Apparently, no study has been undertaken on alterations in cholinesterase activity and its correlation with neurological disorders in clinical case of trypanosomosis in buffaloes. Therefore, the present study was undertaken to evaluate the alterations in cholinesterase activity in clinical cases of

• br Results and Discussion br Conclusion What

  2020-07-25

  

  Results and Discussion Conclusion What we have shown here is that highly specific antagonist can be a very useful tool, can mimic gene KO experiments or even further dissect receptor function. We just took ETA antagonist as an example and found that ETA mediates physiological closure of DA whi

• Brg is a core unit of BAF complex

  2020-07-25

  

  Brg1 is a core unit of BAF complex and is required for the self-renewal and pluripotency of ESCs (Ho and Crabtree, 2010). We confirmed the interaction of DPF2 and BRG1 by immunoprecipitation and showed that these proteins extensively co-localize in the genome. Although both Brg1 and Dpf2 positively

• br Introduction Hematopoietic stem cells and leukemic stem c

  2020-07-25

  

  Introduction Hematopoietic stem clozapine clozaril and leukemic stem cells (HSCs and LSCs, respectively) both have a capacity of self-renewal. Whereas HSCs give rise to all blood lineages during lifetime hematopoiesis, LSCs are responsible for the initiation and propagation of leukemia, as well

• Because of the complexity of

  2020-07-25

  

  Because of the complexity of DNA damage and its repair, several pathways are candidates in HN2-induced DPC repair. Considering the 23kDa molecular weight of MGMT, NER may be ineffective for MGMT-adduct removal. This presumption is supported by that the mRNA level of ERCC1, a core gene in NER pathway

• Previous studies reported that combined administration of li

  2020-07-25

  

  Previous studies reported that combined administration of licorice/GL and TWHF/TP showed reduced toxicity and equal or even potentiated therapeutic efficacy when treating arthritis (YS et al., 2006, YS et al., 2008, Zhang et al., 2007). Our findings that GL reduced exposure to TP in rats confirmed t

16383 records 827/1093 page Previous Next First page 上5页 826827828829830 下5页 Last page