• Our previous study showed that TRIM

  2024-12-19

  

  Our previous study showed that TRIM31 could target TSC1-TSC2 complex and contributed to the clinical cancer progression [6]. In this study, we showed that TRIM31 could directly target p53 for ubiquitous degradation and further mediated anoikis-resistance of HCC cells. To further clarify the role of

• br Experimental section br Results and

  2024-12-19

  

  Experimental section Results and discussion Conclusion Acknowledgement This work was supported by the National Natural Science Foundation of China (Grant Nos. 81401489), the Shanghai Pujiang Program (17PJ1402800) and the Shanghai Sailing Program (Grant No. 14YF1409000). Introduction

• br Current therapies for metabolic

  2024-12-18

  

  Current therapies for metabolic diseases Inborn errors of metabolism caused by deficiency of particular enzymes due to loss of function mutations or deletions have been treated by decreasing the intake of the enzymatic substrate, supplementation with an essential cofactor or vitamin, increasing m

• br Materials and methods br Results and discussion

  2024-12-18

  

  Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P Fmoc-His(Boc)-OH.CHA concentrations significantly increased in chicks after 1 h of refeeding (958 ± 245% of

• This study revealed that EAAT expression was increased weeks

  2024-12-18

  

  This study revealed that EAAT2 I-BET-762 was increased 4–8 weeks after cauterization as our previous work (Park et al., 2009). RGC death could not be blocked despite activation of EAAT2, which is one of glutamate transporters in cone photoreceptors and some bipolar cells, in chronic ocular hyperten

• br Acknowledgments br Introduction Within the

  2024-12-18

  

  Acknowledgments Introduction Within the classical secretory pathway, transmembrane and soluble cargos travel via the endoplasmic reticulum (ER) and Golgi apparatus en route to their final destinations [1]. However, at a post-Golgi level, trafficking routes can diverge. In this context, the tra

• In order to get a better

  2024-12-18

  

  In order to get a better understanding of this synergy, we tested the effect of preliminary incubation of protease k with non-stimulating concentrations of gonadotropins or FSK before subsequent stimulation by FSK or gonadotropins alone, also at sub-stimulating concentrations. We observed that huma

• Adenosine is a ubiquitous homeostatic purine nucleoside that

  2024-12-18

  

  Adenosine is a ubiquitous homeostatic purine nucleoside that accumulates extracellularly in response to metabolic stresses such as hypoxia and inflammation. Activation of either G protein-coupled adenosine receptors (ARs; A1R, A2AR, A2BR, and A3R) by extracellular adenosine can modulate cell signali

• Changes in actin microfilaments are

  2024-12-18

  

  Changes in Annexin V-Cy5 Apoptosis Kit microfilaments are mediated by changes in extracellular matrix, mechanical stimulation or growth factors intracellular signaling. We observed significant changes in a number of intracellular signaling pathways associated with changes in actin dynamics during h

• Brain damage diseases such as cerebral ischemia brain trauma

  2024-12-18

  

  Brain damage diseases, such as cerebral ischemia, brain trauma and infection are characterized by the increase in oxygen free radicals. Therefore, deeper understanding of the character and mechanism of free radical damage in the brain is important to ultimately relieve diseases and promote recovery

• Since the localization of LO depends on phosphorylation we

  2024-12-18

  

  Since the localization of 5-LO depends on phosphorylation, we also analyzed the phosphorylation profile of 5-LO-WT and all isoforms by Western blot using specific BIBW2992 against the phosphorylation sites S271 and S523. Whereas phosphorylation at S271 activates the 5-LO, inhibits nuclear export an

• br Experimental procedure br Introduction

  2024-12-18

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• br The cytochrome P enzyme hydroxylase lyase P

  2024-12-18

  

  The cytochrome P450 enzyme 17α-hydroxylase/17,20-lyase (P450) is involved in the production of the C containing androgen precursors from the C containing steroids such as the pregnanes and progestins (). Steroids such as androstenedione (AD) and dehydroepiandrosterone (DHEA) are therefore synthesi

• br Funding br Ethics br

  2024-12-18

  

  Funding Ethics Conflict of interest Acknowledgements Introduction Hepatic fibrosis occurs in response to different etiologies of chronic liver injury, which is mainly accompanied by pathological DDD107498 of excessive extracellular matrix (ECM) of the liver, as the common reaction of

• Aurora kinases are a conserved

  2024-12-18

  

  Aurora kinases are a conserved family of serine/threonine kinases that are important for the transition through mitosis and amplification and overexpression of Aurora kinases have been implicated in dihydroquercetin and transformation. Aurora B is located at the centromere and controls aspects of k

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