Introduction The generation of an organ requires strict cont

2018-10-20

Introduction The generation of an organ requires strict control of the number and identity of cells generated during development. Zac1 (also known as Plagl1) belongs to an imprinted gene network (IGN), which has been shown to control embryonic growth (Varrault et al., 2006). Accordingly, Zac1 knock

br Resource table Resource details

2018-10-20

Resource table. Resource details RCe008-A (RC-4) was derived from a fresh Phenformin that was surplus to requirement or unsuitable for clinical use. The cell line was derived by whole embryo outgrowth on a chemically defined matrix consisting of laminin, fibronectin, Collagen IV and vitronectin

br Materials methods The derivation and culturing conditions

2018-10-20

Materials & methods The derivation and culturing conditions of hAT-MSCs are thoroughly described in Supplementary Materials and methods section, while details regarding hiPS lines generation and validation are described elsewhere (Kyrkou et al., in press). Results Discussion Human AT-MSCs

tolterodine tartrate br Resource table br Resource

2018-10-20

Resource table Resource details Multiple endocrine neoplasia type 1 (MEN1) (also termed Wermer syndrome) is an autosomal dominant hereditary which is caused by mutations on the tumor suppressor gene MEN1. MEN1 is characterized by tumorigenesis mainly in endocrine organs including parathyroid g

br Materials and methods br Author disclosure statement

2018-10-20

Materials and methods Author disclosure statement Acknowledgments This work was supported by the National Institutes of Health K08 grant number HL111148 (J.L.S.) and R01 grant number HL051387 (D.E.V.). We are especially indebted to patients and their families for participating in this study

We further explored the ploidy levels of human SSCs

2018-10-20

We further explored the ploidy levels of human SSCs with RA and SCF treatment by detecting DNA content. Notably, the percentage of haploid cantharidin was significantly increased in human SSCs by RA and SCF treatment, although spontaneous differentiation of SSCs into haploid cells was observed in c

Main Text There is a growing international market

2018-10-20

Main Text There is a growing international market for unproven stem cell-based interventions advertised on a direct-to-consumer basis primarily over the internet, a phenomenon often referred to as “stem cell tourism” (Ryan et al., 2010; Levine and Wolf, 2012; Regenberg et al., 2009). Studies have e

br Experimental Procedures br Acknowledgments br Introductio

2018-10-20

Experimental Procedures Acknowledgments Introduction Master transcription regulators control the pluripotent gene expression in embryonic stem aldose reductase (ESCs) (Avilion et al., 2003; Chambers et al., 2003; Mitsui et al., 2003; Nichols et al., 1998). X chromosome inactivation (XCI) is

In summary forward genetic analysis by

2018-10-20

In summary, forward genetic analysis by piggyBac gain of function mutagenesis has multiple advantages complimenting genomic and biochemical methods and empowers individual investigators to functionally interrogate the human ES cell genome to elucidate mechanisms underlying biology, disease, and ther

br Results br Discussion In the two dry AMD patients

2018-10-20

Results Discussion In the two dry AMD patients and one SMD patient, increasing subretinal pigmentation developed at the hESC-RPE cell injection site as has been noted previously (Schwartz et al., 2012, 2015). In the second dry AMD patient and the second SMD patient, multiple spots of increased

br Results The levels of TGF

2018-10-20

Results The levels of TGFβ and downstream signaling mediators (activated SMAD2/3) increase in muscle of dystrophic mdx mice with age, correlating to reduced regeneration, angiogenesis and function, and higher fibrosis extent (Ardite et al., 2012; Kharraz et al., 2014; Mann et al., 2011; Vidal et 

br Results br Discussion Two different lineages of BAs

2018-10-20

Results Discussion Two different lineages of BAs have been known. Classical BAs are derived from Myf-5 expressing common progenitors for myoblasts and BAs (Seale et al., 2008). The myoblastic precursors originate from the mesenchymal stem procollagen c proteinase (MSCs). PRDM16 is crucially i

As epigenetic regulatory mechanisms control DNA templated ac

2018-10-20

As epigenetic regulatory mechanisms control DNA-templated activities, including gene transcription, we hypothesized that evaluating the nature and dynamics of epigenetic changes at gene regulatory regions during hepatocyte commitment of hESCs and comparing differences between HLCs and PHHs might ide

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2018-07-29