• The concept of metronomic chemotherapy began in the

  2019-04-15

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum

• In addition to CAF in

  2019-04-15

  

  In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of

• There are important methodological issues affecting

  2019-04-15

  

  There are important methodological issues affecting the study of child mortality inequalities on the basis of survey data. McKinnon and colleagues relied on rigorous analytical tools to study these changes, and in some aspects—for example the graphical display of the statistical significance of chan

• br Discussion br Conclusions br Conflicts of interest br Int

  2019-04-11

  

  Discussion Conclusions Conflicts of interest Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by emotional stress or exercise in patients without organic heart disease and may be polymorphic or bidirectional (Fig. 1) [1–3]. This ventricular arrhythmia

• br Conflicts of interest br Acknowledgment

  2019-04-11

  

  Conflicts of interest Acknowledgment This work was supported, in part, by a grant from the Experimental Research Center ELPEN (Y97/2-12-2013). The funding source had no involvement in the study design, in the collection, analysis and interpretation of data, in the writing of the report, and in

• br This year marks years since countries

  2019-04-11

  

  This year marks 20 years since 189 countries signed the Beijing Declaration and Platform for Action and committed to prioritisation of women\'s empowerment and gender equality. Yet a recently released UN analysis shows that violence against women persists at “alarmingly high levels”. Worldwide, on

• En una de las acciones de

  2019-04-11

  

  En una de las acciones de refriega, los indígenas alzaron d-amphetamine mano a un sargento y lo bajaron por las laderas de la montaña en el sector de Alto Berlín, donde los soldados custodiaban torres de comunicación como muestra de que no deseaban actores armados legales o ilegales en la zona. Esto

• Some studies have shown improvement in

  2018-11-15

  

  Some studies have shown improvement in insomnia following an anti-stress massage [22,23]. It has also been reported that women experiencing insomnia as a symptom of menopause tend to select alternative therapies, particularly body therapies, as their first choice of therapy [24]. In a recent pilot s

• Adan and Natale in a

  2018-11-15

  

  Adan and Natale (2002), in a study conducted in Barcelona involving 2135 individuals with age between 17 and 30 years, verified association between the male gender and eveningness [40]. In the same year, in Brazil, Hidalgo et al. (2003) investigated 318 individuals of the same age, obtaining the sam

• There is evidence of an association between bruxism

  2018-11-15

  

  There is evidence of an association between bruxism and tension, stress, and emotional disturbance [33]; however the influence of socioeconomic status is less clear [4,25]. Of note, our study showed that the presence of bruxism was associated with higher income and socioeconomic class as well as inc

• En este escenario global M xico tiene ante s

  2018-11-15

  

  En este escenario global, México tiene ante sí el reto histórico de trascender su condición de país atrasado en el concierto internacional, y que ante la fallida estrategia de industrialización por sustitución de importaciones, lo llevó a integrarse a través del tlcan en los eslabones bajo y medio d

• br There are two main hypotheses to

  2018-11-15

  

  There are two main hypotheses to guarantee consistency for this estimator: the temporal trajectory of the indicator mean studied in the control group represents what would occur with the treatment group if there was no treatment, i.e., the possible improvement of an indicator for the state of Cear

• Replicating prior studies we found that

  2018-11-15

  

  Replicating prior studies, we found that non-anxious individuals are capable of learning from positive outcomes, regardless of age (Moutsiana et al., 2013). However, this ability was impaired in both anxious adolescents and adults. Although anxious adolescents recalled expected Barasertib Supplier

• Obviously the wor http www

  2018-11-15

  

  Obviously, the work done in this process has nothing to do with propellant force. In other words, the work A used to define the propellant force in the second statement should not be the work done by the free expansion of the propellant gas. Furthermore, it hiv protease inhibitor is not clear whet

• The lineage of differentiation is uncertain

  2018-11-15

  

  The lineage of differentiation is uncertain. Nerve sheath and cartilaginous origin were commonly suggested differentiation types according to some immunohistochemical and ultrastructural studies, but are still not conclusively proven. All typical OFMT are immunoreactive for vimentin (100%), and 94%

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