br Experimental Procedures br Acknowledgments br Introductio

2018-10-20

Experimental Procedures Acknowledgments Introduction Master transcription regulators control the pluripotent gene expression in embryonic stem aldose reductase (ESCs) (Avilion et al., 2003; Chambers et al., 2003; Mitsui et al., 2003; Nichols et al., 1998). X chromosome inactivation (XCI) is

In summary forward genetic analysis by

2018-10-20

In summary, forward genetic analysis by piggyBac gain of function mutagenesis has multiple advantages complimenting genomic and biochemical methods and empowers individual investigators to functionally interrogate the human ES cell genome to elucidate mechanisms underlying biology, disease, and ther

br Results br Discussion In the two dry AMD patients

2018-10-20

Results Discussion In the two dry AMD patients and one SMD patient, increasing subretinal pigmentation developed at the hESC-RPE cell injection site as has been noted previously (Schwartz et al., 2012, 2015). In the second dry AMD patient and the second SMD patient, multiple spots of increased

br Results The levels of TGF

2018-10-20

Results The levels of TGFβ and downstream signaling mediators (activated SMAD2/3) increase in muscle of dystrophic mdx mice with age, correlating to reduced regeneration, angiogenesis and function, and higher fibrosis extent (Ardite et al., 2012; Kharraz et al., 2014; Mann et al., 2011; Vidal et 

br Results br Discussion Two different lineages of BAs

2018-10-20

Results Discussion Two different lineages of BAs have been known. Classical BAs are derived from Myf-5 expressing common progenitors for myoblasts and BAs (Seale et al., 2008). The myoblastic precursors originate from the mesenchymal stem procollagen c proteinase (MSCs). PRDM16 is crucially i

As epigenetic regulatory mechanisms control DNA templated ac

2018-10-20

As epigenetic regulatory mechanisms control DNA-templated activities, including gene transcription, we hypothesized that evaluating the nature and dynamics of epigenetic changes at gene regulatory regions during hepatocyte commitment of hESCs and comparing differences between HLCs and PHHs might ide

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2018-07-29