• Introduction In the midst of the detrimental effects of unst

  2018-10-25

  

  Introduction In the midst of the detrimental effects of unstable movement in exchange rate, the negative penalties of exchange rate volatility are of great concern. High uncertainty of exchange rate makes expectations over the future price level more uncertain. In a country where the economy depend

• Proteolytic enzymes and proteases are necessary for

  2018-10-24

  

  Proteolytic enzymes and proteases are necessary for the degradation of surrounding proteins and other tissue components and thus play crucial roles in multiple steps of cancer invasion and metastasis (Edwards and Cancer, 1998). Among the proteases, uPAR and cathepsin B are often detected in higher a

• The following are the supplementary data

  2018-10-24

  

  The following are the supplementary data related to this article. Acknowledgments This work was supported by the Andrew L. Warshaw, MD Institute for Pancreatic Cancer Research, Massachusetts General Hospital, and by NIH-P01CA117969 to SPT. We would like to Thank Dr. Timothy Wang, Dorothy L. and

• Histological analysis showed the quantitative difference

  2018-10-24

  

  Histological analysis showed the quantitative difference in perinucleolar oocytes between WT and PGC-depleted dnd morphants, consistent with the observation that the ratio of perinucleolar oocytes in total germ ras gtpase dictates gonadal fate (Uchida et al., 2002). Our findings suggest that oocyte

• PARK is a ubiquitously expressed protein and its ubiquitinat

  2018-10-24

  

  PARK2 is a ubiquitously expressed protein, and its ubiquitination of outer mitochondrial membrane is a prerequisite step in mitophagy-mediated removal of damaged mitochondria. However, PARK2 abnormalities in Cyclosporin A other than neurons fail to display the selective loss of a particular populat

• br Towards successful transplantation of

  2018-10-24

  

  Towards successful transplantation of human ITT Where there is no risk of neoplastic contamination of the tissue that could lead to retransmission of cancer atipamezole back to the cured patient, autotransplantation of testicular tissue pieces may be considered for fertility restoration. It has

• Here we report for the first time that the mouse

  2018-10-24

  

  Here, we report for the first time that the mouse eye possesses a primitive c-Kit+ cell that is self-renewing, clonogenic and multipotent, the three critical identifiers of tissue specific stem/progenitor pkm2 (Weissman, 2000). In addition, lineage tracing techniques in vivo demonstrate that the ma

• Previous reports have shown that

  2018-10-24

  

  Previous reports have shown that inhibition of GSK3 by CHIR promotes mESC self-renewal through activation of Wnt/β-catenin signaling pathway (Martello et al., 2012). In the absence of Wnt ligand or CHIR, T cell factor 3 (TCF3) occupies the promoter regions of many pluripotency genes (e.g., Nanog, Es

• In previous tumor studies we have

  2018-10-24

  

  In previous tumor studies, we have used a p53-null syngeneic mouse model to mimic p53 loss of function in human breast cancer. This model was developed by transplanting p53-null mammary epithelium into the cleared mammary fat pads of wild-type, syngeneic Balb/c-recipient mice, resulting in spontaneo

• It is often pointed out that tumor cells can escape

  2018-10-24

  

  It is often pointed out that tumor EZ Cap Reagent GG (3\' OMe) can escape immune cells by changing their antigenicity through the modification of targeted peptide sequences or reduction of HLA-molecule expression (Schreiber et al., 2011). This is usually the case when immune therapies with antigen-

• We sought to determine whether

  2018-10-24

  

  We sought to determine whether T cell-derived iPSCs (TiPSCs) could be used to analyze neurological diseases. Several issues regarding the utilization of TiPSCs in neurological studies remain unresolved. First, previous studies indicated that each iPSC clone retains an epigenetic memory relating to t

• Below we highlight what has been

  2018-10-24

  

  Below, we highlight what has been preserved and what is new in the 2016 ISSCR Guidelines for Stem Cell Research and Clinical Translation. We also provide a window into our deliberations and describe key elements of the process from which these revised guidelines emerged. Specific recommendations emb

• miRNAs are known to regulate the expression of

  2018-10-24

  

  miRNAs are known to regulate the expression of multiple targets via binding to 3′ UTR. Our finding that the miR-29 family regulates global DNA methylation and demethylation adds another role to the list of common regulatory roles of miRNAs. The miR-29 family was known to regulate ECM proteins in phy

• Although RA is sufficient to promote the development of

  2018-10-24

  

  Although RA is sufficient to promote the development of spermatogenic glucokinase from mSSCs to spermatocytes, the Sertoli cell co-culture increases further the induction efficiency. Severe apoptosis of the germ cells were observed under both the feeder-free and the co-culture conditions, indicating

• IGF and PI K signaling in regenerating muscle was tightly

  2018-10-24

  

  IGF and PI3K signaling in regenerating muscle was tightly regulated across multiple levels and temporally, especially during the transition between myoblast proliferation and differentiation. In the early period, IGF1 was upregulated and quickly followed by increases in expression and chromatin remo

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