• br Discussion A familial platelet disorder

  2019-05-10

  

  Discussion A familial platelet disorder with a propensity to myeloid malignancy (FPD/MM) was first reported in 1978 and since then approximately 30 pedigrees with RUNX1 germline mutations have been reported in the literature [9,11]. The RUNX1 gene is composed of 10 exons (1–6, 7A, 7B, 7C and 8).

• This is the first report describing the occurrence of

  2019-05-10

  

  This is the first report describing the occurrence of HLH in a patient with refractory CLL who had started Ibrutinib treatment. Hemophagocytic lymphohistiocytosis (HLH) is a rare and frequently fatal disorder characterized by an ineffective T-cell and NK response resulting in an exuberant cytokine p

• Cardiologic examination and detailed analysis of lead

  2019-05-09

  

  Cardiologic examination and detailed analysis of 12-lead rest ECG were performed by an experienced cardiologist (E.C.) and reevaluated by another independent cardiologist (S.R.). According to Groh et al., severe ECG abnormality included at least one of the following: rhythm other than sinus; PR inte

• Numbers studies also showed that the MSCs have

  2019-05-09

  

  Numbers studies also showed that the MSCs have the capacity to differentiate into multiple mesenchymal tissues both in vitro and in vivo, including osteoblast [25,34], condrocyte [35,36], adipocyte [37,38], tendon [39,40], skeletal muscle cells [39], cardiomyocyte [41,42] and hematopoietic supportin

• Treatment administered thereafter involved approaches Becaus

  2019-05-09

  

  Treatment administered thereafter involved 2 approaches. Because the patient had LV dyssynchrony with LBBB, we planned to implant a biventricular pacing device. A CRT-D was chosen despite the absence of syncope and non-sustained ventricular tachycardia. The choice of the device was based on the pres

• In Tara Mangal and colleagues report the

  2019-05-09

  

  In , Tara Mangal and colleagues report the results of their case-control study into the persistence of poliomyelitis in Nigeria, which identified low vaccine efficacy, poor vaccine coverage, suboptimum agomelatine immunity, rejection and refusal of vaccine, and lack of awareness as issues responsib

• Using the finding of a reduction in

  2019-05-09

  

  Using the finding of a 12% reduction in neonatal mortality, Pitt and colleagues show that, even though the reduction in neonatal mortality was relatively modest, the intervention would still be cost-effective. With further statistical modelling they calculate that such an intervention is likely to b

• ldh assay br Conflict of interest br Introduction Garrigue e

  2019-05-09

  

  Conflict of interest Introduction Garrigue et al. reported that atrial overdrive pacing reduces the number of sleep ldh assay episodes in pacemaker patients without heart failure [1]. However, this finding has not been replicated in subsequent investigations [2–5], although some meta-analysis

• br Discussion Intriguingly in a case

  2019-05-08

  

  Discussion Intriguingly, in a case report about elevation of skeletal enzymes in ultramarathon runners, the CK level reached its peak value one day after the run, had a ∼4-day plateau, and began to decline after a few more days. The sustained increase of plasma CK in this athlete was quite differ

• In addition to inducing IKs dysfunction

  2019-05-08

  

  In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor

• It s springtime for surgery declared

  2019-05-08

  

  “It\'s springtime for surgery!” declared Meena Cherian at the launch of the at the end of April. It certainly seems so. In a few days\' time, WHO Member State representatives will gather at the 68th World Health Assembly to discuss, among other things, the adoption a on surgical care and anaesthes

• En segundo lugar el buen

  2019-05-08

  

  En segundo lugar, el buen vivir, siguiendo el planteamiento original de la conaie de una crítica GS-9973 la economía del mercado, plantea como uno de sus ejes principales la creación de un sistema económico social y solidario que reconoce al ser humano como sujeto y fin que “tiene por objetivo garan

• Los dedos son las cuatro mil verdades

  2019-05-08

  

  Los dedos son las cuatro mil verdades vistas por los ojos de las moscas. La labor del escritor, entonces, se pone rsv virus la altura de la labor del detective: encontrar los diez dedos, descubrir el cuerpo flotando en el agua, dar con una cabeza que yace en el fondo de un río y nombrarla por su nom

• Two important issues affect our interpretation of

  2019-05-08

  

  Two important issues affect our interpretation of these findings. First, many women chose institutional delivery (53% of deliveries were at hospitals in Sazawal and colleagues\' trial, and 64% in Semrau and colleagues\' trial). The latest WHO guidelines recommend application of chlorhexidine to the

• br A hallmark of the

  2019-05-08

  

  A hallmark of the past decade has been the remarkable progress made in reducing maternal and child mortality, an achievement credited in some measure to the Millennium Development Goals. The reduction in child deaths from an estimated 12·7 million under-5 deaths in 1990 to fewer than 6 million dea

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