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In the context of metabolism the MMEKO mouse develops age
2020-08-04
In the context of metabolism, the MMEKO mouse develops age-related obesity. This is thought to be mediated through hyperphagia [28], although the exact mechanism is unclear. Interestingly, whole-body knockdown or overexpression of the Drosophila MME homolog NEP4 decreases larval food intake and decr
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For patients with BCC who underwent surgical excision and
2020-08-04
For patients with BCC who underwent surgical excision and had positive surgical margin(s), either reoperation or close follow-up can be options (Kumar et al., 2000; Kumar et al., 2002). This decision depends on the factors like histopathologic pattern, tumour size and location that increases recurre
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In addition to proteasome the UPP also includes ubiquitin ub
2020-08-04
In addition to proteasome, the UPP also includes ubiquitin, ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), ubiquitin ligases (E3s) and deubiquitinases (DUBs), which collectively work in three discrete and successive steps: 1) the substrate is tagged by the covalent attachme
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The photocleaving properties of were studied by performing X
2020-08-04
The photocleaving properties of 1 were studied by performing ΦX174 photocleavage assays. Light irradiation of the mixtures of increasing amounts of 1 with supercoiled DNA caused>90% supercoiled form relaxation and approximately 5% of linearization for the higher concentrations of 1 (1:10bp and 1:2bp
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Recent studies have reported the
2020-08-03
Recent studies have reported the co-localization of total and pDDRs in Hydrocortisone receptor with collagen [20], [21], [35]. Our results expand these observations by showing that higher-order assembly of DDRs into receptor clusters and/or filamentous structures may associate with different morpho
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Statistical Analysis All graphical data
2020-08-03
Statistical Analysis: All graphical data were prepared and statistical analyses were performed using GraphPad Prism. Statistical significance between the differences of means was determined by performing a One-way Analysis of Variance followed by the Bonferroni\'s post-hoc test. Results CDK5 is
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br Acknowledgments br Introduction Social
2020-08-03
Acknowledgments Introduction Social software applications – such as wikis, weblogs, and social networking sites (SNS) – have recently attracted organizational researchers’ attention (e.g., Kane and Fichman, 2009, Kane et al., 2014a). The impressive growth of public social web sites, like Faceb
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Introduction The physiological significance of hypoxia
2020-08-03
Introduction The physiological significance of hypoxia is undisputed, although largely over looked in the cancer therapeutics field focused on DNA-damage induced by ionizing radiation or drug treatment. Regions of hypoxia occur during a range of diverse biological situations including embryogenesi
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For mounting an effective immune response by secretion
2020-08-03
For mounting an effective immune response by secretion of pro- or anti-inflammatory mediators and phagocytosis of invading pathogens or cellular debris during an infection, deployment of specific subsets of macrophages to the site of inflammation must be temporally and spatially strictly regulated.
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br In order to determine the physiological roles
2020-08-03
In order to determine the physiological roles of WT (wild type) EWSR1, Dr. Lee\'s group established a conventional Ewsr1 KO mouse [38]. Since then, the Ewsr1 KO (−/−) mouse model has successfully been utilized to decipher many important in vivo roles of EWSR1 (Fig. 1). EWSR1 deficiency alters m
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br Acknowledgements br Introduction DNA ligases play an impo
2020-08-03
Acknowledgements Introduction DNA ligases play an important role in genome replication and DNA damage repair. DNA ligases are classified into two families according to their nucleotide substrate requirement: ATP-dependent ligases and NAD-dependent ligases [1], [2]. The ligase reaction consists
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Attempts to define the function
2020-08-03
Attempts to define the function of individual DGK domains have resulted in inconclusive results. ATP binding motifs corresponding to the glycine-rich loops found in protein kinases (GxGxxG consensus sequence; Hanks et al., 1988, Hemmer et al., 1997) were identified in the first C1 and catalytic doma
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As it was recently found native
2020-08-03
As it was recently found [28], native α-synuclein interacts with anion-binding groove between O and R (or P and Q) subunits of GAPDH which comprises NAD+-binding pocket and active site (Fig. 2A). In all 10 simulations, α-synuclein bound to this region of GAPDH (Fig. 2D, E). The following GAPDH resid
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Triacetyl Resveratrol Experiments on the rat model of E coli
2020-08-03
Experiments on the rat model of E. coli pyelonephritis, performed to investigate the relationship between the acute inflammatory processes and the permanent kidney damage (Brooks et al., 1974), have demonstrated a positive correlation between the degree of free radical-mediated renal injury and the
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In conclusion we demonstrated phenoconversion
2020-07-31
In conclusion, we demonstrated phenoconversion of CYP3A in stable kidney transplant recipients, and that higher plasma indoxyl sulfate concentrations in these subjects may be involved in the phenomenon. The present findings suggest that dose adjustment of drugs metabolized by CYP3A may be needed in
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