• Elevated methylglyoxal levels also contribute to carbonyl st

  2021-10-23

  

  Elevated methylglyoxal levels also contribute to carbonyl stress, cytotoxicity, DNA damage, apoptosis and cell death. These mechanisms may be important for normal aging of the nervous system as well as for the development of neurodegenerative diseases such as Alzheimer's and Parkinson's disease wher

• Although we showed that RBL H Sc cells

  2021-10-23

  

  Although we showed that RBL-2H3 Sc98 bruton's tyrosine kinase took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family,

• br Materials and methods br

  2021-10-23

  

  Materials and methods Results Discussion Quercetin is a relatively abundant bioactive flavonoid with a wide variety of documented physiological effects, which has gained popularity as a nutritional supplement [40]. There is increasing interest in quercetin's anticancer properties (for recen

• An important difference between glucokinase and the other

  2021-10-23

  

  An important difference between glucokinase and the other hexokinases is that it has a much lower affinity for glucose, such that it is not saturated at physiological blood glucose concentrations (Wilson, 1995, Wilson, 1997, Wilson, 2003, Wilson, 2004, Cárdenas et al., 1998). In addition, glucokinas

• Considerable evidence links sustained GCG

  2021-10-23

  

  Considerable evidence links sustained GCG administration to the reduction of food intake, enhancement of energy expenditure and weight loss in rodent and human studies [16], [17], [18]. Moreover, patients presenting with GCG-producing tumors frequently manifest severe weight loss, through mechanisms

• The significance of A and tau as therapeutic targets is

  2021-10-23

  

  The significance of Aβ and tau as therapeutic targets is not only derived from pathological evidence of postmortem brain but also from biochemical analysis of cultured human neurons. This is largely based on the induced pluripotent stem cell (iPSC) technology that has been established to study Aβ, t

• Introduction Protein tyrosine phosphorylation plays

  2021-10-22

  

  Introduction Protein-tyrosine phosphorylation plays key roles in a variety of intracellular signaling pathways involved in cell proliferation, differentiation, gene expression, cell adhesion, and metabolic changes [1]. While receptor-type tyrosine kinases localize to the plasma membrane, most of no

• Histamine H and H receptors

  2021-10-22

  

  Histamine H1 and H2 receptors are considered as low affinity receptors (pKi of 4.2 and 4.3 respectively), whereas histamine H3 and H4 receptors as a high affinity receptors (pKi of 8 and 8.2 respectively) (Schreeb et al., 2013). Therefore it might well be that other histamine receptors might be invo

• Interestingly in vivo infusion and uptake of Ang

  2021-10-22

  

  Interestingly, in vivo infusion and uptake of Ang II in intact mice indicated that multiligand endocytic receptor megalin has at least some role in the uptake of Ang II and the downstream signaling process in proximal tubule CB-5083 (PTCs) in vivo [173]. Earlier in vivo studies showed that PTCs of

• br Activation of soluble guanylate cyclase

  2021-10-22

  

  Activation of soluble guanylate cyclase The molecular steps involved in sGC activation have evolved significantly over the last several years. The key studies are outlined below, but here we provide an overall summary. The activation mechanism of sGC was initially proposed to be relatively simple

• The Scribble complex localizes to the leading edge in

  2021-10-22

  

  The Scribble complex localizes to the leading edge in response to integrin engagement. There, Scribble controls the activation Rac and PAK via the Rac GEF β-Pix (Bahri et al., 2010), which is required for collective cell migration (Omelchenko et al., 2014). However, on the rear edge, Scribble can be

• GPR GPR GPR GPR and GPR

  2021-10-22

  

  GPR80, GPR81, GPR82, GPR93 and ψGPR79 all shared identities to P2Y GPCRs or P2Y-like oGPCRs. Previously, at least three different nucleotide receptor phenotypes have been observed in mammalian tissue, including GPCRs activated by Dibutyryl-cAMP, sodium salt nucleotides (e.g. P2Y1 and P2Y11), uridine

• E7080 synthesis Acute in vivo experiments were performed in

  2021-10-22

  

  Acute in vivo experiments were performed in normoglycemic 129SVE mice to confirm GPR119 activation and corresponding E7080 synthesis control. GIP release was utilized as a biomarker for target receptor engagement and plasma GIP levels were measured 45min after oral dosing (). Both 3 and 10mg/kg pro

• br Materials and methods br Results br Discussion In

  2021-10-22

  

  Materials and methods Results Discussion In nerve terminals, Na+-dependent glutamate transporters of the plasma membrane are responsible for the maintenance of low (non-toxic) extracellular glutamate concentrations and accomplish uptake of glutamate into the HET0016 of neurons and glial ce

• Attempting to further elucidate the role of glucagon

  2021-10-22

  

  Attempting to further elucidate the role of NAD/NADH Quantitation Colorimetric Kit and activation of the Gcgr without the influence of GLP-1, we used DT-Gcg mice with acute knockdown of all proglucagon products. This mouse model has previously been shown previously to have a normal total islet area

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