• Expanded BMSC here underwent intramembraneous bone formation

  2018-10-22

  

  Expanded BMSC here underwent intramembraneous bone formation on β-TCP, based on an apparent absence of a cartilage intermediate, in line with previous reports (Krebsbach et al., 1997; Martin et al., 1997; Mendes et al., 2002, 2004). Unless subjected to chondrogenic pre-induction, BMSC/β-TCP construc

• br Results and Discussion In order to

  2018-10-22

  

  Results and Discussion In order to identify regulators of ISC behavior, we carried out a screen using esgGal4 in the posterior midgut. From this screen, Dbr was identified as a candidate. Single esg+ cells are interspersed in young flies (Figure 1A). In aged flies, esg+ cells are clustered, enlar

• The adventitia of large vessels is highly vascularized

  2018-10-22

  

  The adventitia of large vessels is highly vascularized. As such, we are not surprised that our multi-parameter analytical flow cytometric analysis revealed a relatively high prevalence of Phenyl sulfate expressing surface markers consistent with the endothelial lineage, namely CD31. We also detected

• The environment in the postnatal

  2018-10-22

  

  The environment in the postnatal cerebral cortical may not be permissive for all lineage-reprogrammed astroglial iap apoptosis to differentiate into iNs. In fact, after transplantation in the neurogenic subventricular zone, we observed that both cerebellar and cortical astroglia nucleofected with A

• In our study ERK and

  2018-10-20

  

  In our study, ERK and JNK inhibitors effectively inhibited the migration of glioma ldk378 while the effect of the p38 inhibitor was not as significant. Hence, we further evaluated the effect of downregulation of uPAR and cathepsin B on the expression of ERK and JNK. Reduction in the expression leve

• In the present study we

  2018-10-20

  

  In the present study, we introduce a novel cell surface protein, CD98, that is specifically expressed on the cells of the basal layer and, in addition, remains stably expressed after a multitude of proteolytic treatments. We show that purified CD98high cells are able to induce tumor growth upon seri

• Introduction The generation of an organ requires strict cont

  2018-10-20

  

  Introduction The generation of an organ requires strict control of the number and identity of cells generated during development. Zac1 (also known as Plagl1) belongs to an imprinted gene network (IGN), which has been shown to control embryonic growth (Varrault et al., 2006). Accordingly, Zac1 knock

• br Resource table Resource details

  2018-10-20

  

  Resource table. Resource details RCe008-A (RC-4) was derived from a fresh Phenformin that was surplus to requirement or unsuitable for clinical use. The cell line was derived by whole embryo outgrowth on a chemically defined matrix consisting of laminin, fibronectin, Collagen IV and vitronectin

• br Materials methods The derivation and culturing conditions

  2018-10-20

  

  Materials & methods The derivation and culturing conditions of hAT-MSCs are thoroughly described in Supplementary Materials and methods section, while details regarding hiPS lines generation and validation are described elsewhere (Kyrkou et al., in press). Results Discussion Human AT-MSCs

• tolterodine tartrate br Resource table br Resource

  2018-10-20

  

  Resource table Resource details Multiple endocrine neoplasia type 1 (MEN1) (also termed Wermer syndrome) is an autosomal dominant hereditary which is caused by mutations on the tumor suppressor gene MEN1. MEN1 is characterized by tumorigenesis mainly in endocrine organs including parathyroid g

• br Materials and methods br Author disclosure statement

  2018-10-20

  

  Materials and methods Author disclosure statement Acknowledgments This work was supported by the National Institutes of Health K08 grant number HL111148 (J.L.S.) and R01 grant number HL051387 (D.E.V.). We are especially indebted to patients and their families for participating in this study

• We further explored the ploidy levels of human SSCs

  2018-10-20

  

  We further explored the ploidy levels of human SSCs with RA and SCF treatment by detecting DNA content. Notably, the percentage of haploid cantharidin was significantly increased in human SSCs by RA and SCF treatment, although spontaneous differentiation of SSCs into haploid cells was observed in c

• Main Text There is a growing international market

  2018-10-20

  

  Main Text There is a growing international market for unproven stem cell-based interventions advertised on a direct-to-consumer basis primarily over the internet, a phenomenon often referred to as “stem cell tourism” (Ryan et al., 2010; Levine and Wolf, 2012; Regenberg et al., 2009). Studies have e

• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Master transcription regulators control the pluripotent gene expression in embryonic stem aldose reductase (ESCs) (Avilion et al., 2003; Chambers et al., 2003; Mitsui et al., 2003; Nichols et al., 1998). X chromosome inactivation (XCI) is

• In summary forward genetic analysis by

  2018-10-20

  

  In summary, forward genetic analysis by piggyBac gain of function mutagenesis has multiple advantages complimenting genomic and biochemical methods and empowers individual investigators to functionally interrogate the human ES cell genome to elucidate mechanisms underlying biology, disease, and ther

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